Comparative measurements of bone mineral density and bone contrast values in canine femora using dual-energy X-ray absorptiometry and conventional digital radiography

authored by: K. Lucas, I. Nolte, V. Galindo-Zamora, M. Lerch, C. Stukenborg-Colsman, B. A. Behrens, A. Bouguecha, S. Betancur, A. Almohallami, P. Wefstaedt
Abstract: Background: Aseptic loosening due to bone remodelling processes after total hip replacement is one common cause for revision surgery. In human medicine, dual-energy X-ray absorptiometry (DEXA) is the gold standard for quantitative evaluation of bone mineral density, whereas in veterinary medicine conventional radiography is used for follow-up studies. Recently, a method has been described using digital X-ray images for quantitative assessment of grey scale values of bone contrast. Therefore, the aim of the present study was to evaluate the correlation of bone mineral density (BMD) measured by DEXA with grey scale values (GV) measured in digital X-ray images (RX50, RX66) ex vivo. Results: The measured GV in the chosen X-ray settings showed on average a good correlation (r = 0.61) to the measured BMD with DEXA. Correlation between the two X-ray settings was very good (r = 0.81). For comparisons among regions of interests (ROIs) a difference of 8.2% was found to be statistically significant, whereas in the case of RX50 and RX66 differences of 5.3% and 4.1% were found to be statistically significant. Conclusions: Results indicate that measuring absolute changes in bone mineral density might be possible using digital radiography. Not all significant differences between ROIs detectable with DEXA can be displayed in the X-ray images because of the lower sensitivity of the radiographs. However, direct comparison of grey scale values of the periprosthetic femur in one individual patient during the follow-up period, in order to predict bone remodelling processes, should be possible, but with a lesser sensitivity than with DEXA. It is important that the same X-ray settings are chosen for each patient for follow-up studies.
Organisation(s): Institute of Metal Forming and Metal Forming Machines
External Organisation(s): University of Veterinary Medicine of Hannover, Foundation
Universidad Nacional de Colombia
Hannover Medical School (MHH)
Type: Article
Journal: BMC veterinary research
Volume: 13
ISSN: 1746-6148
Publication date: 11.05.2017
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: General Veterinary
Sustainable Development Goals: SDG 3 - Good Health and Well-being
Electronic version(s): https://doi.org/10.1186/s12917-017-1047-y (Access: Open)
: Details in the research portal "Research@Leibniz University"

BibTeX

@article{be9f63b576e542fbb98b43ecc67fa96a,
title = "Comparative measurements of bone mineral density and bone contrast values in canine femora using dual-energy X-ray absorptiometry and conventional digital radiography",
abstract = "Background: Aseptic loosening due to bone remodelling processes after total hip replacement is one common cause for revision surgery. In human medicine, dual-energy X-ray absorptiometry (DEXA) is the gold standard for quantitative evaluation of bone mineral density, whereas in veterinary medicine conventional radiography is used for follow-up studies. Recently, a method has been described using digital X-ray images for quantitative assessment of grey scale values of bone contrast. Therefore, the aim of the present study was to evaluate the correlation of bone mineral density (BMD) measured by DEXA with grey scale values (GV) measured in digital X-ray images (RX50, RX66) ex vivo. Results: The measured GV in the chosen X-ray settings showed on average a good correlation (r = 0.61) to the measured BMD with DEXA. Correlation between the two X-ray settings was very good (r = 0.81). For comparisons among regions of interests (ROIs) a difference of 8.2% was found to be statistically significant, whereas in the case of RX50 and RX66 differences of 5.3% and 4.1% were found to be statistically significant. Conclusions: Results indicate that measuring absolute changes in bone mineral density might be possible using digital radiography. Not all significant differences between ROIs detectable with DEXA can be displayed in the X-ray images because of the lower sensitivity of the radiographs. However, direct comparison of grey scale values of the periprosthetic femur in one individual patient during the follow-up period, in order to predict bone remodelling processes, should be possible, but with a lesser sensitivity than with DEXA. It is important that the same X-ray settings are chosen for each patient for follow-up studies.",
keywords = "Bone mineral density, Bone remodelling, Canine, DEXA, Digital radiography, Femur",
author = "K. Lucas and I. Nolte and V. Galindo-Zamora and M. Lerch and C. Stukenborg-Colsman and Behrens, {B. A.} and A. Bouguecha and S. Betancur and A. Almohallami and P. Wefstaedt",
note = "Funding information: This study was performed in association with the subproject D6 of the collaborative research center 599: “Sustainable degradable and permanent implants out of metallic and ceramic materials”. The authors wish to thank the German Research Foundation (DFG) for its financial support.",
year = "2017",
month = may,
day = "11",
doi = "10.1186/s12917-017-1047-y",
language = "English",
volume = "13",
journal = "BMC veterinary research",
issn = "1746-6148",
publisher = "BioMed Central Ltd.",
number = "1",
}